Study record managers: refer to the Data Element Definitions if submitting registration or results information. This study will evaluate the safety and effectiveness of two drugs-dextromethorphan and topiramate-in treating orofacial mouth and face pain. Dextromethorphan, a commonly used cough suppressant, and topiramate, an anti-seizure medicine, block certain receptors on brain and spinal nerve cells that may cause the cells to produce electrical discharges and pain. Patients 18 years of age and older with oral and facial pain with trigeminal nerve damage and who have had pain daily for at least 3 months may be eligible for this study. Candidates will be screened with a medical history, physical examination, blood tests and psychiatric evaluation.
Tourette syndrome - Diagnosis and treatment - Mayo Clinic
Topiramate is a broad-spectrum antiepileptic medication that is used as monotherapy or in combination with other medications to treat epilepsy in both adults and children. Despite the benefits of topiramate as listed above, including weight neutrality, patients are still prone to discontinue their medications. This problem is highly prevalent among patients with mental health conditions, most notably schizophrenia and bipolar disorders. In particular, patients may abruptly discontinue their antiepileptic medications secondary to experiencing adverse effects, even if they have been made aware of the potential for such adverse effects through education provided by a pharmacist. Prescribers and other health care providers must be aware of potential adverse effects that may arise with the commencment and maintenance of antiepileptic therapy. Less common but serious adverse effects include hemiparesis, hypesthesia, abnormal coordination, chest pain, anemia, and bone marrow suppression. As noted above, a common adverse effect of topiramate is paresthesia, which is characterized by abnormal neurologic sensations such as numbness, tingling, burning, prickling, and hypesthesia.
Current Approaches and New Developments in the Pharmacological Management of Tourette Syndrome
Over the past week alone, I have talked to several people about their doctor visits. Each one of them had a different illness and each one of them was prescribed the drug Topamax. I suspect it cannot and the overreach is driven more by marketing than medicine.
There's no specific test that can diagnose Tourette syndrome. The diagnosis is based on the history of your signs and symptoms. A diagnosis of Tourette syndrome might be overlooked because the signs can mimic other conditions. Eye blinking might be initially associated with vision problems, or sniffling attributed to allergies.