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TRA-8 is a murine agonist monoclonal antibody to death receptor 5 DR5 , which is able to trigger apoptosis in DR5 positive human tumor cells without the aid of crosslinking. It has demonstrated cytotoxicity in vitro and in vivo antitumor efficacy to a wide range of solid tumors in murine xenograft models. There were no study-drug—related grade 3 or 4, renal, hepatic, or hematologic toxicities.
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